- Ben Grimm becomes a successful U.S. Airforce pilot and part of the NASA program.
- The Fantastic Four defeat the Mole Man and become the modern era's first super heroes.
- The Fantastic Four encounter their first Skrull on a space mission. They tell no one about the alien.
- The Fantastic Four move into Baxter Building in New York City.
- Johnny Storm discovers an amnesic Namor living homeless on the streets of New York City. The Fantastic Four restore his memory. Namor has a complicated relationship with the surface world.
- The Fantastic Four fight the Red Ghost on the Blue part of the moon and encounter the Watcher.
- The Fantastic Four teams up with Nick Fury to fight the Hate Monger.
- Spider-Man tries to join the Fantastic Four but gets turned down.
- The Impossible Man runs amok in New York City and the Fantastic Four stops him.
- Dr. Doom attacks again and involves fighting him in a microscopic reality.
- The Skrulls capture the Fantastic Four and send impostors back in their place. The Avengers discover the replacement and fight the Skrulls.
- The Fantastic Four discover the Negative Zone. They fight Blastaar.
- Johnny Storm encounters an amnesic Inhuman Medusa. His warm personality doesn't make her an ally.
- The Skrulls create the Super Skrull and unleash him on the Fantastic Four. They barely defeat the villain.
- Medusa, Sandman, The Wizard, and Trapster band together and fight the Fantastic Four as the Frightful Four.
- The Watcher can no longer protect Earth from Galactus. The Fantastic Four with the aid of the Silver Surfer defeat the world devourer with the Ultimate Nullifier.
- The Fantastic Four encounter the Inhumans and reunite Medusa with her people.
- Ronin the Accuser sends a Kree Sentry to destroy the Fantastic Four.
- The Fantastic Four encounter Annihilus in the Negative Zone.